It is widely known that human health can be diagnosed by measuring blood protein. However, it has recently been found that the age of a human can be precisely predicted by the blood protein level.
Aging does not continue at a constant pace
A team from Stanford University's Tony Wis-Korey and colleagues used blood samples from 4263 people aged 18 to 95 to analyze 2925 plasma proteins and find out on December 5, 2019. Was published in the academic journal Nature Medicine .
The research paper also shows that aging does not progress continuously at a constant pace, but progresses rapidly at three points: adolescent age of 34, middle age of 60, and old age of 78. I have.
Proteins are responsible for executing instructions from the cells that make up the body. Therefore, a large change in protein levels means a change in the body.
Physiological aging occurs sharply at 34, 60 and 78
The team measured the levels of 2,925 plasma proteins in each subject, and found that 1379 protein levels were clearly different depending on the subject's age. In addition, the subject's age can be accurately predicted with an error of about three years using 373 of these proteins, and it can be predicted with some accuracy even with 9 proteins.
It has also been shown that irreversible changes in the body due to aging alone, or “physiological aging,” occur rapidly at three points: 34, 60, and 78 years on average. Many proteins stay at the same level for a period of time, rather than rising or falling at a constant pace or maintaining the same level for a lifetime, and suddenly fluctuate up and down at certain points.
Of the 1379 proteins whose levels differed markedly by age, 895 were characterized by gender. It is also attracting attention as one of the results showing that the aging process differs between men and women.
It is expected to be applied to the development of drugs and treatments that delay aging
Wiesbaden = Corey Professor, "young mice of blood, suppresses the deterioration, such as cognitive function associated with aging," in May 2014 of the research results announced, going on a change of the molecule in the blood by aging However, the results of this study will push anti-aging medicine further.
Although it takes another 5 to 10 years for clinical application, blood proteins are used as `` aging biomarkers '' to identify the rapid progression of aging, to develop drugs and treatments to slow aging, It is expected to be applied in various fields, such as early detection of side effects of accelerated drugs.
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